Rejuvant?

Has anyone heard of this?

https://rejuvant.com/Home

 

The speaker presented a talk indicating that users got substantial drop in DNA methylation age results - I seem to recall an average of 8 years after 6 months usage

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    • Allen
    • Allen_Rosenberg
    • 2 yrs ago
    • Reported - view

    I bought 180 500 mg AKG capsules for $15 on Amazon. Rejuvant's $110 monthly subscription price seems steep to me. I know my AKG from Amazon is not time release but in testing did the worms and mice get time release AKG? I think not.

    The Rejuvant people say that they have a patent but on exactly what? For better or for worse, I expect to see copy-cat type extended release AKG hitting the market.  

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    • JGC That sounds like a good protocol. I’ve read about bioperine from LEF. I don’t have access to Dasatinib yet but I did take Fisetin, Quercetin, Resveratrol, with some milk thistle and coconut oil for the first three days of a 5 day fast recently. I did also take some piperlongumine as well. I thought I might get a better effect while fasting. Thanks so much for the tip. I’m going to give it a try.

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    • Fred Cloud 

      One way to interpret information about AKG-rejuvant is that epigenetic age can be reversed in some tissues and in some organs and that the tissue specific rejuvenation and the reduction of epigenetic age of tissues and organs does not translate into a reduction of the epigenetic age of the whole organism.  In other words, the reversed epigenetic age of tissues does not correlate with a reversal of the epigenetic age of the person.

       

      If AKG achieves a tissue specific rejuvenation that makes a human body healthier and less prone to the diseases and the frailty that comes with old age then the result is a healthier body but not a longer lifespan (or maybe only a modest gain in average lifespan).

       

      AKG might compress morbidity and make some tissues/organs healthier and rejuvenated to a younger state. If the epigenetic clock rejuvant use “catch” some tissue specific rejuvenation then I know  what I can expect from AKG. A healthier body but not an expanded lifespan. 

       

      Not all epigenetic clocks are the same, some are good at measuring the biological age of the human body. Others are better at measuring the biological age of organs/tissues and disease related phenotypes. I don’t know which clock Rejuvant used. As far as I have learned, Kennedy himself and rejuvant speaks more about increased healthspan and compressed morbidity than of increased lifespan.

       

      Michael Lustgarten, made a short video about the pros and cons of different epigenetic clocks. Some clocks are better in measuring the general biological ageing vs chronological ageing, Other epigentic clocks are better at measuring disease related changes.

       

      https://www.youtube.com/watch?v=iNnvF1Eh7VE

       

      AKG is a key metabolite in the krebs cycle and by manipulating it we might delay age related diseases and some organ dysfunctions. If this is the case then I know what to expect from it and I keep AKG in my regimen. I guess the choice I have to make is between wait for more data and till then take a leap of faith based studies on mammals or wait for more data and till that arrives stay away from AKG. I stay with AKG for now.  

       

      https://www.lifespan.io/news/a-summary-of-alpha-ketoglutarate/

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      • JGC
      • Retired Professor of Physics
      • JGC
      • 2 yrs ago
      • Reported - view

      Staffan Olsson 

          You wrote: "I don’t know which clock Rejuvant used."  The Rejuvant clock used only 13 methylation sites, while Horvath-based clocks use several hundred.  That suggests that the Revjuvant clock was "cherry-picked" to show evidence of epigenetic reprogramming, and that, as you suggest, actually only a few cell-types were affected.

          I note that in an N=1 self-experiment, jimmy2 did a before/after clock comparison involving taking the Rejuvant product for 6 months.  Using two different commercial DNAme clocks, he found no evidence of epigenetic reprogramming.

          The Rejuvant web site contains lots of misinformation about the DNA methylation process.  Whatever their internal expertise, I suspect that they have some snake-oil salesmen on their payroll, and I would regard any claims about general epigenetic reprogramming with suspicion.  However, the Buck Institute work does indicate some significant AMG benefits (at least for worms an mice), and I plan to add the Swanson version of AMG to my evening supplements  when my order arrives.

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    • Staffan Olsson Various tissues could be rejuvenated at different rates and you would never know because the DNA tested and used for the popular blood based methylation age test like mydnage is only white blood cells.

      So it doesnt look at the various tissues throughout the body. Sometimes it can be misleading when a test says they use 11 sites or 200 sites or thousands of sites, it isnt sites in various tissues in the body, it is sites on the dna of one type of cell, in this case white blood cell.

      Trueme which is what rejuvant uses  is a saliva based test, so I assume they are using cells from your cheek but I would have to verify that.

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      • JGC
      • Retired Professor of Physics
      • JGC
      • 2 yrs ago
      • Reported - view

      Fred Cloud 

          I don't recall the venue (maybe ARDD?), but I do recall a talk by Steve Horvath in which he reported on the DNAm clock readings for various tissue samples from the same human individual.  I think he said that, in general, tissues age at about the same rate.  The exception was the tissue of women's breasts, which age faster than other tissue.   So it is possible to do differential tissue aging studies (but maybe only after an autopsy ☹️).

          I note that one can get DNAm tests done based on saliva or urine (as well as blood), so the those probably do not use white blood cells.

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      • Chris
      • Chris.1
      • 2 yrs ago
      • Reported - view
    • JGC What is your rationale for taking AKG in the evening?

      FWIW I take it first thing in the morning , on an empty stomach. Reason being, better absorption.

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    • aribadabar Just heard that the calcium acts as a buffer to counter it's acidity ie taking on an empty stomach.

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    • Allen
    • Allen_Rosenberg
    • 2 yrs ago
    • Reported - view

    AKG researcher, Dr. Gordon Lithgow was recently interviewed by Modern Healthspan. He doesn't seem to think that the CA from of AKG is superior. Another AKG researcher, Dr. Brian Kennedy was recently interviewed by the Skeekey Science Show. He stated that he saw no advantage of the CA form of AKG. 

    Kennedy has said that maybe the time release form is superior but tests are still being run to determine that. 

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  • I'm on my last 5miligrams of rapamycin and have just become aware of AKG.   Anyone know if they can be taken together?   Just out of caution I thought I'd wait until my 1.25 month rapamycin cycle is through before tanking AKG.    Also, my wife had a horrible case of ocular shingles after supplementing with arginine.  She worries that AKG might set it off again but it seems that would be AAKG not AKG?   Comments.

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      • Allen
      • Allen_Rosenberg
      • 2 yrs ago
      • Reported - view

      Robert Olin I believe that AKG does contain arginine. I would think that anyone prone to shingles should avoid it. As fast as this field is evolving, there is and will be many other options to choose.

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    • Allen Thanks.   She will avoid it.   She still suffer really bad nerve pain.   Is calcium AKG arginine free?

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      • Allen
      • Allen_Rosenberg
      • 2 yrs ago
      • Reported - view

      Robert Olin I called Kirkman Labs. They sell CA-AKG and they told me it is Arginine free. It does cost a little more than AKG, but it's still much less expensive than Rejuvant. However, if extended release is important to you, Rejuvant is currently the only option I know of.

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    • Allen AKG does NOT contain arginine. AAKG is the arginine-containing one.

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      • Allen
      • Allen_Rosenberg
      • 2 yrs ago
      • Reported - view

      aribadabar I was referring to what it by far the most common form in use. That is of course, the arginine containing one. But yes, I should have been clearer. 

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  • Thanks to all of you for the valuable information.  

    Bob

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    • Iðunn
    • Iunn
    • 2 yrs ago
    • Reported - view
    Fred Cloud said:
    Its the ca-akg that creates the sustained release,

     This is incorrect. Ca-AKG is just an AKG salt; it has negligible effects on pharmacokinetics. Rejuvant was formulated for extended-release characteristics.

     

    Fred Cloud said:
    AKG has been found to work also, so I think they just want something unique that they can patent so they can mark the price way up,

    This is fairly obviously not correct: I'm sure they  "want something unique that they can patent so they can mark the price way up," but there's nothing unique about Ca-AKG, and it's certainly not patentable: lots of other people sell it at much lower prices. Rejuvant is more expensive in small part because of the additional cost of formulating an extended-release tablet, but also because the formula includes the additional ingredients (which are researched and patented based on mouse lifespan and frailty studies), the branding, the scientific affiliations, and the fact that it's being used in clinical trials.

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  • The mice got CaAKG with their food throughout the day. I’ll be skipping Rejuvant and just take smaller amounts through the day.

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    • Chuck Frasher my solution is to make a smoothie with the day's dosage of CaAKG and some protein powder and drink it at times through the day, like before and after exercising.

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