High quality, affordable rapamycin (and other anti-aging meds)

Hi everyone. Many of you might not realize it, but IAS has made rapamycin available without a prescription. It is the best price I've ever seen (better even than what I saw in pharmacies in Mumbai a couple months ago).

If you go to:

http://www.antiaging.clinic/

and enter the code "research" you will see the option of buying rapamycin, as well as a selegiline, metformin, and a few other anti-aging meds.

IAS has committed to putting a certain fraction of the revenue (15% I believe) into research.

Because of irritating legal/regulatory challenges, IAS cannot accept credit/debit cards, so you have to pay via wire transfer (e-check is an additional option if you have a bank in the US, probably also Canada). My purchase experience was smooth and quick.

And by the way I've been on rapamycin – 5 mg with a fatty meal (30% better absorption than on empty stomach) once a week – for nearly two months now. Feel fine. Haven't tested my cholesterol yet but the oft-noted side-effect of glucoregulatory dysfunction has not made an appearance. In point of fact, my fasting and postprandial glucose numbers have gone down a touch.

Brian

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    • Snowbird
    • Snowbird
    • 5 yrs ago
    • Reported - view

    Hi Brian,

    I too have been on Rapamycin and Metformin since June 2018. I got my Rapamycin and Metformin from Dr. Allan Green in New York.  I am retired and a full-time RV'er (motorhome) so I am able to travel to where doctors offices are in different states. My homebase is Florida.

    I too take my rapamycin with a fatty meal as since January 2018 I have been on a no-sugar Ketogenic diet (the Whole30 diet is very similar). It is now August 2018 and I have lost 65 lbs., feel great and my lab work has been coming back remarkable. Dr. Green is impressed with my insulin resistance too. I think sugar has a lot to do with aging, the recent obesity epidemic, heart disease, cancer and alzheimers (Alzheimers is now called Type lll diabetes!). 

    In my on-line research I found that the body can survive on either glucose or fat. When the body uses up the glucose it starts burning fat. If the body is burning glucose and creating insulin, it cannot burn fat at the same time.  This is why many people (including me) could not lose weight. I also found out that many cancers need glucose to survive. As I mentioned, regular cells can burn either glucose or fat for energy, BUT cancer can only burn glucose for energy and does not have the ablility to switch over to burning fat, thus the cancer dies.

     

    I now eat healty fats,  like coconut oil, olive oil, avacados and meats from grass fed cows and free range chickens, as the brain needs healthy fats to survive.  And I try not to overload on too much protein as that too can have an adverse effect. Best to fill you plate with healthy dark leafy greens.

    Like 6
      • Danmoderator
      • skipping my funeral
      • dantheman
      • 5 yrs ago
      • Reported - view

      Snowbird "cancer can only burn glucose for energy and does not have the ablility to switch over to burning fat, thus the cancer dies" Unfortunately it's not that simple, some cancers are able to adapt to ketone bodies - see the research of Dr Voltor Longo, there's a shorter version if you look for FoundMyFitness channel on YouTube which has a recent interview. They also talk about ketogenic diets and the evidence that they aren't living up to the hype. The best approach, if there is one, appears to be alternating a normal healthy diet (whole food vegan with the addition of fish if you desire) with water only fasting for the ketone benefits. Longo recommends this, 2x year fasts for athletes who eat right, 4x for healthy folks and more for others. 

      Like 4
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      Dan Mc  I also stated "many" cancers need glucose to survive, knowing that some cancers get around this. I still feel that the best approach is a no-sugar diet, although I'm sure the Food Industry has paid scientists to produce studies that disagree on this point. One scientist in England, I believe, recently wrote articles that "MCT oil is poison"! I have been on a no-sugar diet now since January 2018, lost around 65 lbs., feel great and my lab work shows I'm a lot healthier that I was. That's physical proof for me that I will live longer than I would have, if I had continued eating the way I use to.

      Like 1
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      Dan Mc Whole food vegan is difficult. The brain needs an ample amount of fats. Too many nuts causes high lectin and so does legumes. A raw, uncooked vegan diet is usually high in lectin, as boiling the vegetables decreases the amount of lectin that a person eats. A good book to read is "The Plant Paradox" by Stephen Gundry, M.D. where he explains that many plants adapted themselves for survival by producing toxic and bitter substances so that they would not be eaten. Now that I no longer have sugar cravings, I am leaning more towards a cooked vegan diet but I have to do more study on which foods will give me complete protein (but not too much) and healthy fats, on a daily basis.

      Like 2
      • Danmoderator
      • skipping my funeral
      • dantheman
      • 5 yrs ago
      • Reported - view

      Snowbird Been doing whole food vegan for 30 years, haven't found it hard. Numbers are perfect, biological age is calendar - 20, blah blah. Anyhow not trying to get in an argument, was just relaying Voltar Longo's work and the latest science research he discusses since he is big in the longevity community (he studied with Roy Walford), and that is what the board is about. Regardless if you're happy with what you're doing then stick with that. 

      Like 2
    • Dan Mc Some can tolerate lectins better than others. I too stay away from them along with sugar, dairy, gluten, anything processed or poisoned. 

      Like 1
      • Dennis
      • Retired USAF pilot, biochemist.
      • Dennis
      • 5 yrs ago
      • Reported - view

      immortality Great info! I've been on Rap/Met for a year and started fisetin (discussed elsewhere) a few weeks ago (74, 70kg., bad knees, foot pain 2 yrs. better after fisetin). I see that Dr. Green has added fisetin (senolytic/pain relief) to his protocol. Snowbird, has Dr. Green suggested something like the 1400 mg fis/d x 2 days that I ran across elsewhere or is he using different info? I've followed Dr. Gundry also but am using canned beans that have been pressure cooked which Dr. Gundry says does a pretty good job of neutralizing the lectins.

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      • Don
      • Don
      • 5 yrs ago
      • Reported - view

      Snowbird I don't know why coconut oil has suddenly become a healthy fat. It's highly saturated. Or am I missing something?

      Like 1
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      Don  Hi Don, 

      Dr. Mark Hyman, the Medical Director at Cleveland Clinic’s Center for Functional Medicine, the Founder of The UltraWellness Center, and a ten-time #1 New York Times Bestselling can explain this better than I can:

      Why Saturated Fat Is Not the Enemy

      “Saturated fat has been demonized ever since Ancel Keys’s landmark ‘seven countries’ study in 1970,” writes Aseem Malhotra in a British Medical Journal review appropriately called “Saturated fat is not the major issue.”

      As Malhotra and numerous other researchers point out, correlation is not causation, and Keys neglected to account for many factors that could also contribute to heart disease. Keys cherry-picked his data, conveniently excluding whatever didn’t fit his hypothesis. In fact, the countries he studied that had the highest rates of heart disease also were the countries with the highest intakes of sugar and refined carbohydrates. Was it the fat or the sugar? Turns out it was the sugar!
      Even though critics pointed out these and other fallacies in Keys’s work, the public bought into the saturated-fat-is-harmful myth, avoiding it like the plague for decades and choosing instead inflammatory vegetable oils and trans fats in fake foods like margarine.

      The truth becomes much more complicated. Some fats do raise cholesterol, whereas others lower cholesterol. Even when saturated fat does, the type of cholesterol becomes more important than cholesterol itself. Saturated fat does raise the LDL or bad cholesterol, but it also raises the good or HDL cholesterol. But sugar lowers HDL cholesterol. And it is the ratio of total to LDL cholesterol that is a far more important predictor of heart attacks than LDL cholesterol itself.
      Quality becomes paramount here. The saturated fat in a fast-food bacon cheeseburger will have an entirely different effect than saturated fat in coconut oil.

      Let’s use grass-fed beef as an example. Although lower in saturated fat than grain-fed beef, roughly 40 to 50 percent of the fat in grass-fed beef is saturated.

      Compared with grain-fed beef, grass-fed beef contains more stearic acid, a saturated fat that doesn’t increase cholesterol. In fact, one study in the journal Lipid found stearic acid lowered LDL cholesterol.

      Grass-fed beef contains lower amounts of palmitic acid and myristic acid, two saturated fats that can potentially raise cholesterol.

      Interestingly, researchers find when folks consume more saturated fat—especially from healthy sources like coconut oil—their “good” HDL cholesterol increases and their “bad” LDL decreases. Saturated fat in foods like extra virgin coconut butter fuels your mitochondria, provides anti-inflammatory benefits, and could even improve your cholesterol numbers.

      (I am on a no-sugar diet, have coconut milk every day (love the taste and very hunger satisfying) and also put MCT Oil in my coffee. And my lab work verifies the researchers findings mentioned above!).

      Like 2
      • Dennis
      • Retired USAF pilot, biochemist.
      • Dennis
      • 5 yrs ago
      • Reported - view

      Snowbird Yes, lot of docs swearing by coconut oil! I've been using it for over a year! Just swishing (oil pulling) w/ it can lessen or eliminate dental visits/cost (at least for me)!

      Like 1
      • Don
      • Don
      • 5 yrs ago
      • Reported - view

      Snowbird , Thanks for that detailed comment. Much to think about! 

      Like
      • Iðunn
      • Iunn
      • 5 yrs ago
      • Reported - view

      Snowbird 

      1. Dr. Mark Hyman, the Medical Director at Cleveland Clinic’s Center for Functional Medicine, the Founder of The UltraWellness Center, and a ten-time #1 New York Times Bestselling Author, is a quack:

      https://www.salon.com/2009/03/12/mark_hyman/

      https://badsciencedebunked.com/2015/09/10/trick-or-tweet-dr-mark-hyman-exposed/

      https://scienceblogs.com/insolence/2010/10/05/mark-hyman-deceives-about-science-resear

      https://sciencebasedmedicine.org/tag/mark-hyman/

      2. It is a canard of denialists on the saturated fat-atherosclerosis connection to ramble on about the actual and purported problems with Keys' research, often plagiarizing journalist Gary Taubes since they haven't actually read his work:

      Fat in the Diet and Mortality from Heart Disease: A Plagiaristic Note | The Science of Nutrition

      ... and as if no research on the subject had been done since the 1960s on the subject. In fact, the case has continued to strengthen as subsequent research has filled in gaps and limitations of Keys' original work, and many of the supposed flaws in Keys' work only exist in Taubes' and his plagiarists' minds. For instance, the false claim about ignoring the association between sugar and CVD:

      Keys neglected to account for many factors that could also contribute to heart disease. Keys cherry-picked his data, conveniently excluding whatever didn’t fit his hypothesis. In fact, the countries he studied that had the highest rates of heart disease also were the countries with the highest intakes of sugar and refined carbohydrates. Was it the fat or the sugar? Turns out it was the sugar!

      Um, no.

      "However, as found in the analysis of the five-year follow-up data (Keys 1971), the correlation is accounted for by the inter-correlation of sucrose with saturated fatty acids in the diet. Partial correlation analysis showed that, with dietary saturated fat held constant, the correlation between dietary sucrose and the incidence of coronary heart disease is not significant (r=0.13). On the other hand, with sucrose held constant in the partial correlation analysis, the correlation of coronary incidence rate with the mean percentage of calories from saturated fat is r=0.62."

      Keys A, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Karvonen MJ, Kimura N,  Menotti A, Mohacek I, Nedeljkovic S, Puddu V, Punsar S, Taylor HL, Van Buchem FS. 1980. Seven countries. A multivariate analysis of death and coronary heart disease. Cambridge, MA; Harvard University Press.

      For more, Check out this WHITE PAPER from the True Health Initiative on the Seven Countries Study.

      I see you're on a zero-sugar diet; I think that's a great idea, at least as far as added sugars go. But you and everyone concerned about longevity should restrict their saturated fat intake too — something harder but not impossible to do on a ketogenic diet (if you really do eat keto — it's much easier if you're just whole-foods-low-carb).

      Like 2
      • Danmoderator
      • skipping my funeral
      • dantheman
      • 5 yrs ago
      • Reported - view

      Snowbird Don  Coconut oil is very popular these days, let's examine what properties it has. First, the way your body reacts to dietary oil is that it gets no processing. Once in the GI tract it immediately gets dumped into your bloodstream, which causes a inflammation response from the endothelial lining. This is easy to test, just get a blood draw after an oily meal, and you'll have a test tube with a thick head of oil on it once it gets a chance to separate from the plasma. Also you can measure homocysteine which will elevate (not sure about WBC, but I would expect it goes up also). 

      Anyhow all your fat cells have special 'gateways' on your bloodstream that have a purpose; when they see free fat in the blood stream they pull it out and store. When the bloodstream is clear they take fat from the stores and meter it into the blood stream (based on caloric need signaling). So the fat goes unaltered from GI to your belly (and elsewhere). An interesting side effect of this is you can get a sample of fat from somebody and tell what they're eating. For example, eat pigs and you will have pig fat (the exact form) layered around your body. 

      Plant fats are different, because they are bound up with the lignin's and plant fibers, which takes work for your body to extract. So the fat, once freed later in the GI tract, slowly meters out into the blood stream without causing endothelial inflammation, and the actual caloric content is lower than free fat because of this work spent to get at it. Note that caloric content is simply measured at the FDA but burning the sample and measuring the heat released. 

      Now the form of the fat, saturated, unsaturated and so forth does have various minor effects on the blood stream, but compared to the macro effects these are not terribly significant. The research shows that it depends on the macro conditions of the person eating it - if they are unhealthy, free fat will make it worse. If they otherwise are healthy and live well, they can tolerate it better. For older folks who have depressed AMPK which leads to belly and organ fat I think free oil is doing them no favors. 

      FWIW, a short bit on dietary fat. Generally it can be observed that macro nutrients (protein, carbohydrates and fat) have macro effects, and micronutrients (vitamins, minerals and all the plant phytochemicals that we find in food, supplements and pharmaceuticals) have subtle, targeted effects. Are there significant micronutrients in coconut oil? Like all free fats the answer is the same - no, and unfortunately the biggest is iron which you don't really want. 

      Like 2
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      DanMcL  When I read reports about how macro nutrients (protein, carbohydrates and fat) react in the body I also have to wonder what type of diet the person being tested is on. What does an "oily meal" consist of? MCT oil (medium chain tryglycerides) made from coconut oil goes directly to the mitochondria to be burned up as energy. That is if you don't mix carbohydrates with oil, as an insulin spike will stop the burning of fat!  High carbohydrate diets increase fat storage; "From the lips to the hips", and make fat stay in the bloodstream a lot longer. High carbohydrate is also responsible for increasing LDL, the particles that stick to the endothelial lining and accumulate as plaque. Fat is no longer the culprit in heart attacks, although there are many scientists (some paid by the food industry) that will disagree with this. Sugar is the real culprit but when it is mixed with fat it becomes even more dangerous. I would like to see new studies done on the bodies responses to dietary oil after a person has been on a no-sugar diet like ketogenics (non-grain meats, free range poultry and low glycemic organic vegetables.

      Like
      • Danmoderator
      • skipping my funeral
      • dantheman
      • 5 yrs ago
      • Reported - view

      Snowbird 

      What does an "oily meal" consist of? 

      Free oil - any oil including coconut. It gets transported around the body via the blood stream. It's an easy test, my brother in law is a lab tech, he or any could demonstrate. 

      made from coconut oil goes directly to the mitochondria to be burned up as energy

      Citation? I found a paper studying phospholipid cell membrane effects from coconut oil, but nothing on coconut oil 'feeding' mitochondria, other than some promotional sites. Otherwise it doesn't make sense as the mitochondria produce cellar energy in the form of CoQ10 (by the kilogram for your entire body every day), they certainly don't 'feed' off oil. This is HS biology, that mitochondria work from glucose which come from carbohydrates, here's a quote

      Glucose and other carbohydrates made by plants during photosynthesis are broken down by the process of aerobic cellular respiration (requires oxygen) in the mitochondria of the cell. ... ATP is the energy-carrying molecule produced by the mitochondria through a series of chemical reactions.

      Simple carbohydrates spike insulin, but complex carbohydrates don't, the 'glycemic load' can be found for any common food. Anything below 50 is fine (nearly all natural plant foods). 

      High carbohydrate is also responsible for increasing LDL

      It's far more complex than that. To start study cholesterol particle size (large 'fluffy' versus small 'spikes'. You can get a test for this). Continuing deposits don't happen because of cholesterol, they occur because the site is prepared by endothelial lining irritation from poor lifestyle choices. 

      Sugar is the real culprit but when it is mixed with fat it becomes even more dangerous.

      Sugar is a problem, as is alcohol which is 'super sugar', but it's not because they're carbohydrates but simply refined ones. Again we get back to refining - concentrating, either in carbs, protein or fat (in the form of oil) is a good thing taken too far. 

      ketogenics

      Don't know. Ketogenic diets are all the fad now, a mistaken one unfortunately. The data is clear that our bodies run on glucose and benefit from short term ketosis, like a 3-4 day fast once a month to once every six months, depending on your health level (ref Dr Voltor Longo @ UCLA). Long term ketosis is not what our bodies were designed for. But it doesn't stop people from doing it. 

       

       Best,

      Like 3
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      DanMcL 

       You had mentioned, “It’s easy to get a blood draw after an oily meal” which I now realize you meant that the subject eat only fats before the test. Again, since the subject may be accustomed
      to eating carbs, the body doesn’t automatically switch over to burning fat, which can give the impression that no fat is being burned. 

      I did not mention “coconut oil feeding mitochondria”. I mentioned Medium Chain Tryglycerides (MCT) going directly to the mitochondria for energy. But I also mentioned that having carbs with
      MCT oil, stops this process. I suggest you Google “MCT oil - Mitochondria” rather than coconut oil. Your post attacks all oils as bad. Olive Oil is touted as a healthy oil. I agree that “Man does not live on oil alone”. I also feel there is a lot of people, especially in the U.S., and other countries eating the Western diet could benifit from trying a ketogenic diet (not the old Atkins)
      for at least a short time. Walking past the grocery store’s pastries and the candy bars at the checkout will be difficult for a couple of weeks.

      I don’t advocate long term ketosis (elimination of all forms of glucose) either and nor does most people on a ketogenic diet. Once someone reaches his/her ideal weight, there is no need
      for ketosis and it is beneficial for someone’s health to include low glycemic organic vegetables
      so the body doesn’t just burn fat.

      You mentioned, “The data is clear and our bodies need glucose”. Our bodies can switch from burning glucose to burning fat. It takes a couple of weeks, sugar withdrawals, weight (fat) loss, and a heightened awareness. Fasting is good too, but many people that are addicted to carbs cannot fast to where is it helpful, or binge after.  Refined carbs, which the Food Industry puts in almost everything (baby food too!) light up the same parts of the brain as does cocaine. Many parts of High School textbook biology books are outdated as is the FDA food pyramid. 

      Rather that going round and round where you feel that a person only has to cut back on the food he or she is eating, and try to eat a balanced meal, I feel this has not worked for most people. Especially when consumers do not read the labels on the foods they are purchasing and how the for-profit Food Industry (watch the DVD “FED UP” does not care about our health. I suggest that you read, “Eat Fat, Get Thin” by Dr. Mark Hyman. He backs his information with “new” scientificstudies (footnotes to all the studies). 

      The body is a very complicated thing. We are ALL learning new information and what was thought as "Gospel" just yesterday can turn out to be different today. Also everyone has to be aware of how greed for money, wanting scientific recognition, and businesses that don't want consumers to changescan influence our food choices.

      Like
      • James F
      • James_Fernow
      • 5 yrs ago
      • Reported - view

      immortality I have a friend who is sensitive to lectins, but I eat a lot of lectin-containing foods and don't notice any symptoms.

      Like 1
    • Snowbird
    • Snowbird
    • 5 yrs ago
    • Reported - view

    Hi Brian,

    If anyone wants to get lab work without having to go to a physician, they can go on-line to www. health-tests-direct.com

      Dr. Green gave me this website address. You do have to pay for the lab work yourself, but a good thing is that they are affiliated with two lab draw companies that have facilities in every State in the U.S.  I like Quest labs and have used them twice.

    Like 1
    • Snowbird Is there a certain test that is suggested to check aging markers 

      Like
    • Rawin
    • Rawin
    • 5 yrs ago
    • Reported - view

    Hi Brian 

    Could you please tell me how to take rapamycin I know it should be 5mg per week but for how many weeks. 

    Thank you I appreciate the support. 

    Like 2
  • Snowbird, thanks for sharing your experience. An amazing success story!

    Rawin, first, I need to stress that this is an experimental protocol. And I don't want to be offering medical advice illegally. But the idea promulgated by Dr. Green and other physicians and researchers is that one should take rapamycin permanently – assuming one doesn't have any serious side-effects. But it's always important to test biomarkers before and at various points after to make sure it's helping.

    Note that some researchers speculate that taking a break for a month or so every four to six months might not be a bad idea. But the truth is, no one knows. Our group is supporting research to try to get answers to the question of dosing. We should know more within a year or two.

    Brian

    Like 4
    • Snowbird
    • Snowbird
    • 5 yrs ago
    • Reported - view

    Hi Braian and Rawin,

      I just wanted to add that Dr. Green did not just prescribe my Rapamycin and Metformin. He continues to follow my progress. He gave me a treatment plan where he requests specific lab work (Fasting Blood Sugar, Insulin, HgA1c, Chemestry Panel, Lipid Panel, CBC) for one month, 3 months, 6 months and 1 year, that I e-mail to him to evaluate. He also recomments certain supplements and exercise. 

      I had looked into buying overseas rapamycin, but I wonder about the quality and also whether the U.S. Post Office would confiscate the drug before it reached me. Also I prefer having a professional physician that has been familiar with this rapamycin antiaging therapy ( he even uses it himself) rather than going it alone.  I like being able to correspond with him through e-mails (he responds back the same day!) should any adverse side-effects arrive.

    So far my lab work from www.health-tests-direct.com requested by Dr. Green has shown good improvements. Dr. Green is happy with the results so far, and I have joined a gym to maintain muscle as I lose weight.

    David

    Like 2
  • David, just a quick reply about the overseas source I recommended: the company has been in business for many years, and the quality is excellent. Life Extension would not have agreed to work with them had that not been the case.

    And I have never heard of anyone in the US having a problem with shipments from them being intercepted.

    Like
      • Snowbird
      • Snowbird
      • 5 yrs ago
      • Reported - view

      BrianMDelaney  

      Hi Brian, Yes, IAS is a good company. I found them on-line about 10 years ago and have an account with them. I have ordered products in the past and have received them with no problem. Back then they put a paper in the box, just for the Post Office explaining that Americans have a legal right to small quantities of manufactured drugs for self use. The only problem I, and probably many others had at that time, was that U.S. credit card companies denied the transaction because it was an overseas order. IAS has since resolved the payment problem by asking customers to wire the money to them. I always worried about putting in a large expensive order and whether the Post Office would disregard the letter when they inspected the box and confiscate the drugs. I had no problems with my orders and I understand others have not had any problems. I think another good thing is that the plain-wrapped box comes from England rather than another country that would raise suspicion at the Post Office.

      Like 2
    • I had to sign an NDA to view the COA – obviously, since it would contain propriety information. IAS sent it to me, and I can confirm that the rapamycin they sell (RapaPro) is produced in an EU country, and that it is high quality. I just ordered two more bottles. I think I'm going to up my dose to 6.25 mg (one and a quarter pills). The scale-up from the mouse studies suggests that as much as 10–12 mg might be optimal for age-reversal purposes. But scaling up to human-equivalent doses is of course an art as much as it is a science. If I get unpleasant side-effects, I'll go back down.

      Like 1
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