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Self-Experimentation
Share your story of trying or designing a promising age-reversal protocol.
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Bio-Fisetin, a x25 Boost in Bioavailability?
One of the big problems with senolytic flavenoids like Fisetin and Quercetin is that they have a very low solubility in water and poor survival in the digestive tract,…
JGC
Retired Professor of Physics
JGC
3 yrs ago
13
replies
1058
4
Last reply
UB
2 yrs ago
Self-Experimentation
Longevity Achieved
Recently received my results on my biological age. To my surprise, my biological age is 15. The process to get to this point was difficult. My formula has proven itself over and over.…
Richard Brook
Richard_Brook
2 yrs ago
38
replies
1007
1
Last reply
Spasov
2 yrs ago
Self-Experimentation
Rapamycin in humans
I'm cautious on pharmaceuticals but am considering Rapamycin. Downsides are cost, difficulty to source and potential side effects (some people suffer from stomach issues IIRC).…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
41
replies
943
1
Last reply
Alex
11 mths ago
Self-Experimentation
Mechanism for Immortality
OK guys, here goes. This is controversial so I apologize beforehand. All you need is NMN because it repairs DNA damage and it boots energy via the mitochondria.…
Chan
Chan
4 yrs ago
23
replies
920
Last reply
Chan
2 yrs ago
Self-Experimentation
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to…
JGC
Retired Professor of Physics
JGC
4 yrs ago
40
replies
876
2
Last reply
Dan Nave
2 yrs ago
Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
JohnnyAdams
moderator
Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
JohnnyAdams
4 yrs ago
22
replies
874
Last reply
Stevan Lieberman
2 yrs ago
Self-Experimentation
Dr Peter Attia on Rapamycin
Peter Attia is somebody I follow after seeing him in discussions with Dr Rhonda Patrick, both of whom are researchers in longevity. He switched from surgery to longevity and has practices in NYC and…
Dan
moderator
skipping my funeral
dantheman
updated
5 yrs ago
8
replies
854
3
Last reply
are we there yet
5 yrs ago
Self-Experimentation
Canagliflozin - A One Month Report, Its Good
I've been using Canagliflozin for the past month and really like it. It moderates blood glucose levels and makes it really easy to lose weight. I've lost about 10 lbs in 3 weeks,…
Brin Chikovski
Brin_Chikovski
updated
2 yrs ago
18
replies
807
6
Last reply
Alex K. Chen
1 yr ago
Self-Experimentation
Green tea and green tea extracts
Green tea benefits (and how to get them).
Staffan Olsson
Staffan_Olsson
4 yrs ago
43
replies
749
1
Last reply
Karl
4 yrs ago
Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
Charles Grashow
Charles_Grashow
3 yrs ago
21
replies
725
1
Last reply
Jared
1 yr ago
Self-Experimentation
D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
JGC
Retired Professor of Physics
JGC
updated
1 yr ago
33
replies
706
4
Last reply
Michael_123
1 yr ago
Self-Experimentation
Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
Andrew P K Yap
Andrew_P_K_Yap
3 yrs ago
21
replies
679
Last reply
Michael
3 yrs ago
Self-Experimentation
DHEA protocol?
I'm looking into supplementing with DHEA - suggestions and protocols to follow? I understand you need to do blood test before and during to establish dosage, thoughts? I'm post 50,…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
6
replies
673
1
Last reply
Dan
moderator
5 yrs ago
Self-Experimentation
Berberine and Melatonin - can this reverse aging of cells?
I am using an unusual mix of Melatonin (taken in the middle of the night,early morning really) and Berberine. This video explains the reasons why this has the potential to demethylate the epigenome…
John Hemming
John_Hemming
2 yrs ago
9
replies
647
1
Last reply
John Hemming
2 yrs ago
Self-Experimentation
Apigenin: An Alternative Way of Boosting NAD+
At the recent Ending Age-Related Diseases 2021 online conference, Dr. Eric Verdin of the Buck Institute gave a talk in which he described the mechanism behind the well-known drop in NAD+ with age,…
JGC
Retired Professor of Physics
JGC
2 yrs ago
22
replies
643
5
Last reply
Staffan Olsson
2 yrs ago
Self-Experimentation
Did anyone experience acute inflammation after senolytics?
Hello, I have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. It is a condition that involves chronic inflammation. I tried 3 days of high dose Fisetin the last 3 days (1000mg/day).…
Phoenix
phoenix
4 yrs ago
7
replies
612
1
Last reply
Andrew P K Yap
3 yrs ago
Self-Experimentation
Help: Drastic results on DNA biological age test
Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
Vega Rejuvinated
Vega_Rejuvinated
2 yrs ago
22
replies
597
1
Last reply
Bruce B
7 mths ago
Self-Experimentation
Self-experimentation with variety of supplements and drugs
Greetings, I am 67, male, with type 2 diabetes, heart disease and high blood pressure. Current prescription drugs I take per doctor's order: 2000 mg metformin, 45 mg actos, 80 mg lipitor, 2.…
Kim Mackey
Kim_Mackey
4 yrs ago
4
replies
581
Last reply
JOHN
4 yrs ago
Self-Experimentation
Replacing Hormones to Optimal Levels
I’ve been experimenting with exogenous testosterone for over 15 years. At almost 73 I have been able to build and keep muscle. I eat a diet high in protein, lower in carbs and healthy fats.…
Sharon Smith
Sharon_Smith
2 yrs ago
27
replies
576
5
Last reply
Arizona Kid
2 yrs ago
Self-Experimentation
NAD+ and Cancer
A post on Longecity.org four days ago entitled " NAD+ and Cancer" links to a recent Wistar Institute news release that cautions that boosting NAD+ levels in older animals leads to increased risk of…
Bob S.
Bob_S
5 yrs ago
14
replies
572
Last reply
Jay Orman
2 yrs ago
Self-Experimentation
Young plasma treatments in Tampa, Florida
My name is Howard Chipman MD and I have been treating patients with young plasma for anti-aging, dementia and other age related disorders for over a year with good results.…
Dr. Chipman
Dr_Chipman
6 yrs ago
3
replies
559
4
Last reply
Daniel Stephenson
4 yrs ago
Self-Experimentation
Quercetin recomendations
I have just ordered some Dasatinib using the link in the other thread here. I have started to look to get Quercetin as well and I see many options to order it online.…
Jeff Fuja
Jeff_Fuja
4 yrs ago
20
replies
558
Last reply
Gleb Merkurev
3 yrs ago
Self-Experimentation
Current longevity protocol: Should I add rapamycin?
This is my first post here, and I’m hoping to get some insights from people with similar protocols. In particular, I’m curious to hear people’s perspective on rapamycin given my current regimen.…
Simon Smith
Simon_Smith
2 yrs ago
26
replies
552
2
Last reply
Peter H. Howe
1 yr ago
Self-Experimentation
dasatinib (Dasa-Pro)
'NOTICE: By the end of July IAS will be offering dasatinib (Dasa-Pro) in 12x 40mg double-scored tablets for $99.99 this will be uploaded to www.antiaging.…
CSC
CSC
4 yrs ago
13
replies
521
4
Last reply
Erik A Aronesty
2 yrs ago
Self-Experimentation
Which Dasatinib and Quercetin dosing regimen for longevity?
I have read about two different dosing regimens: 3 consecutive daily doses a week repeated for three weeks based on weight at a 1 to 10 ration based on weight (IE: for a 165lb person,…
Randall James
Randall_James
4 yrs ago
8
replies
519
2
Last reply
Florin
4 yrs ago
Self-Experimentation
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