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Self-Experimentation
Share your story of trying or designing a promising age-reversal protocol.
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Did anyone experience acute inflammation after senolytics?
Hello, I have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. It is a condition that involves chronic inflammation. I tried 3 days of high dose Fisetin the last 3 days (1000mg/day).…
Phoenix
phoenix
4 yrs ago
7
replies
612
1
Last reply
Andrew P K Yap
3 yrs ago
Self-Experimentation
Trehalose
Has anybody researched or tried trehalose to kill senescent cells? I have just come across it in the literature, apparently it stimulates AMPK like Metformin does,…
Koo
Koo
4 yrs ago
1
reply
95
Last reply
Andrew P K Yap
3 yrs ago
Self-Experimentation
7 months taking rapamune
I have lived in Mexico for 9 years. After catching an article about rapamycin I found that I could get it here, without a prescription. Farmalisto in Mexico City to be exact but they do not ship to…
Dale Duke
Dale_Duke
4 yrs ago
1
reply
241
3
Last reply
uzoma iwuagwu
4 yrs ago
Self-Experimentation
Lisinopril and Self Experimentation.
Has anyone had any problems with metformin whilst on Lisinopril drug ? Possible interactions are mentioned on advice sites. Dasatinib and Lisinopril also get a mention in this regard.…
Seaside
Seaside
4 yrs ago
10
replies
130
Last reply
MSS
4 yrs ago
Self-Experimentation
Hyperbaric oxygen therapy
Hi, What is hyperbaric oxygen therapy and how it will helpful for patient? Researcher Shai Efrati share complete information regarding such question. Hope this will help many patients.
Cherith
Cherith
4 yrs ago
1
reply
111
Last reply
Mark Thimineur
4 yrs ago
Self-Experimentation
Here is another Doctor Who prescribes rapamycin in Las Vegas.
I thought I would provide the name of my Doctor who does prescribes rapamycin but his practice is different from Dr. Green in New York. I have found him to be very knowledgeable and extremely…
John Mcgough
John_Mcgough
4 yrs ago
130
1
Self-Experimentation
LDL-C reduction with diet and supplements (no statins)
Hi everyone, I recently came across some interesting videos about the optimal levels of LDL-C at the website, http://plantpositive.com/ . The author of the videos includes screenshots of the…
Maximus Peto
Researcher, website & forum admin
Maximus
5 yrs ago
14
replies
484
2
Last reply
Ajax
4 yrs ago
Self-Experimentation
Which Dasatinib and Quercetin dosing regimen for longevity?
I have read about two different dosing regimens: 3 consecutive daily doses a week repeated for three weeks based on weight at a 1 to 10 ration based on weight (IE: for a 165lb person,…
Randall James
Randall_James
4 yrs ago
8
replies
521
2
Last reply
Florin
4 yrs ago
Self-Experimentation
Rapamycin and APOE4 gene.
According to Dr. Alan Green, Rapamycin is particularly effective in APOE4 carriers, ameliorating the effects of atherosclerosis and Alzheimer's. Does anyone have any experience with either of these…
Jonathan Horwitz
Jonathan_Horwitz
4 yrs ago
12
replies
315
Last reply
MAC
4 yrs ago
Self-Experimentation
DMSO for Increased Flavenoid Solubility and Bioavailability?
The problem with the bio-delivery of senolytic flavenoids like Quercetin and Fisetin is that they are insoluble in water. Therefore, there is a good chance that if taken orally,…
JGC
Retired Professor of Physics
JGC
5 yrs ago
3
replies
406
1
Last reply
Asclepius
4 yrs ago
Self-Experimentation
Dasapro Dasatinib from IAS Reliable
Hello, Does anyone have any reason to think the Dasapro branded Dasatinib from IAS would not be reliable? Do they have a good reputation and do they do third party testing of their products?…
Phoenix
phoenix
4 yrs ago
1
reply
151
1
Last reply
Mark McGovern
4 yrs ago
Self-Experimentation
Dasatinib testing -- Information about ordering testing for dasatinib and rapamycin, and other compounds
Information about ordering testing for purity and content of dasatinib and rapamycin, and other compounds, has been created. That info, and a lot more that's needed for their safe use,…
JohnnyAdams
moderator
Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
JohnnyAdams
4 yrs ago
2
replies
130
1
Last reply
Maximus Peto
4 yrs ago
Self-Experimentation
Green tea and green tea extracts
Green tea benefits (and how to get them).
Staffan Olsson
Staffan_Olsson
4 yrs ago
43
replies
752
1
Last reply
Karl
4 yrs ago
Self-Experimentation
Weekly Rapamycin/Sirolimus Therapy and Diarrhea?
Is anyone else experiencing chronic diarrhea as a result of weekly dosing (6mg/week) of Sirolimus? If so, have you found any method of dealing with it other than stopping?
Jason Frey
Jason_Frey
4 yrs ago
6
replies
224
Last reply
Jason Frey
4 yrs ago
Self-Experimentation
Hyperbaric Oxygen Therapy
Hi there, Are you heard about HBOT. HBOT helps wound healing by bringing oxygen-rich plasma to tissue starved for oxygen. Wound injuries damage the body's blood vessels,…
Cherith
Cherith
4 yrs ago
58
Self-Experimentation
Suppliers for Metformin(Glycomet), Rapamycin(Sirolimus) and Dasatinib(Sprycel)
For Metformin(Glycomet) https://www.alldaychemist.com/glycomet-500mg-sr.html For Rapamycin(Sirolimus) https://www.alldaychemist.com/siromus-1mg.html For Dasatinib(Sprycel) https://www.bonhoahealth.…
Patrick McHargue
Patrick_McHargue
4 yrs ago
222
1
Self-Experimentation
Albearth’s Self-Experimentation
My self-experimentation dates back to 2008 and continues to this day. These experiments have been effective and have helped my entire body. As much as this self-experimentation has done me so well,…
Albearth Reyes
Albearth_Reyes
4 yrs ago
139
Self-Experimentation
Reversing arteriosclerotic disease
I think the forum could benefit from the topic “reversing arteriosclerotic disease”. This since arteriosclerosis is one of the main culprits that shorten the life of many human beings.…
Staffan Olsson
Staffan_Olsson
4 yrs ago
11
replies
361
3
Last reply
Staffan Olsson
4 yrs ago
Self-Experimentation
Metformin: worth it? and what to expect
Hello all. I got my Doctor to give me a prescription for Metformin. I have read about its possible age-reversing effects, but I have also read about some possible significant side effects,…
Jeff Bennion
Jeff_Bennion
updated
5 yrs ago
35
replies
1357
1
Last reply
Cherith
4 yrs ago
Self-Experimentation
Kaufmann Protocol Analysis
Dr. Sandra Kaufman, an MD anesthesiologist with an interest in aging, wrote a 2017 book entitled The Kaufmann Protocol: Why We Age and How to Stop It, in which she describes her approach to…
JGC
Retired Professor of Physics
JGC
4 yrs ago
9
replies
308
2
Last reply
Dan
moderator
4 yrs ago
Self-Experimentation
Should you get a micronutrient test?
Imagine my excitement as the moment finally arrived - the comprehensive results from my 15 vials of blood and four detailed blood tests that I completed at NextHealth arrived in my inbox.…
Dr Nick Engerer
The Longevity Blog
Dr_Nick_Engerer
4 yrs ago
1
reply
87
Last reply
Karl
4 yrs ago
Self-Experimentation
Relaxin (RLX)
Hi Everyone, Has anyone looked at sourcing & using RLX? I've had an AVR operation 8 months ago & my EF has gone from 67 (12 months pre-op) to 55 (pre-op) to 35 (post-op).…
Trevor Bingley
Trevor_Bingley
4 yrs ago
40
Self-Experimentation
Ursolic acid
I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
Staffan Olsson
Staffan_Olsson
4 yrs ago
63
Self-Experimentation
enhancing NAD precursor effectiveness
Therapeutic doses of NR and NMN in studies are usually much larger than the suggested amount on the label. Chromadex NR studies usually use a gram or more of the stuff,…
Ajax
Ajax
4 yrs ago
6
replies
381
3
Last reply
Dorian Gray
4 yrs ago
Self-Experimentation
Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
Not sure how to take this. Anyone more knowledgeable care to comment? https://www.biorxiv.org/content/10.1101/863357v1
Patrick McHargue
Patrick_McHargue
4 yrs ago
3
replies
164
Last reply
David H
4 yrs ago
Self-Experimentation
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